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  • Product Name2-CYANO-5-FLUOROBENZYL BROMIDE
  • CasNo. 421552-12-7
  • MFC8H5BrFN
  • MW214.037
  • Purity
  • Appearance
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Product Details

CasNo： 421552-12-7

MF： C8H5BrFN

Factory Supply High Purity 421552-12-7 with Cheap Price, Buy High Grade 2-Cyano-5-fluorobenzyl bromide

  • Molecular Formula:C8H5BrFN
  • Molecular Weight:214.037
  • Vapor Pressure:0.01mmHg at 25°C 
  • Refractive Index:1.564 
  • Boiling Point:264.468 °C at 760 mmHg 
  • Flash Point:113.746 °C 
  • PSA：23.79000 
  • Density:1.591 g/cm3 
  • LogP:2.59228 

2-CYANO-5-FLUOROBENZYL BROMIDE(Cas 421552-12-7) Usage

InChI:InChI=1/C8H5BrFN/c9-4-7-3-8(10)2-1-6(7)5-11/h1-3H,4H2

421552-12-7 Relevant articles

2-((4-Arylpiperazin-1-yl)methyl)benzonitrile Derivatives as Orally Available Inhibitors of Hepatitis C Virus with a Novel Mechanism of Action

Jiang, Xinbei,Tan, Jiali,Wang, Yixuan,Chen, Jinhua,Li, Jianrui,Li, Jianrui,Jiang, Zhi,Quan, Yanni,Jin, Jie,Li, Yuhuan,Li, Yuhuan,Cen, Shan,Li, Yanping,Peng, Zonggen,Peng, Zonggen,Li, Zhuorong

, p. 5972 - 5989 (2020)

Although the direct-acting antivirals re...

Palladium-Catalyzed Tandem Carbonylative Diels-Alder Reaction for Construction of Bridged Polycyclic Skeletons

Wang, Siyuan,Zhou, Yangkun,Huang, Hanmin

supporting information, p. 2125 - 2129 (2021/04/05)

A palladium-catalyzed tandem carbonylati...

NEW TYPE OF ANTIVIRAL COMPOUND

-

Paragraph 0024, (2018/07/06)

Provided are a new aromatic cyanogen com...

Annulation of o-Quinodimethanes through N-Heterocyclic Carbene Catalysis for the Synthesis of 1-Isochromanones

Janssen-Müller, Daniel,Singha, Santanu,Olyschl?ger, Theresa,Daniliuc, Constantin G.,Glorius, Frank

supporting information, p. 4444 - 4447 (2016/09/09)

The activation of 2-(bromomethyl)benzald...

421552-12-7 Process route

4-fluoro-2-methylbenzonitrile
147754-12-9

4-fluoro-2-methylbenzonitrile

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

Conditions
Conditions Yield
With N-Bromosuccinimide; toluene-4-sulfonic acid; In tetrachloromethane; for 4h; Heating;
86%
With N-Bromosuccinimide; toluene-4-sulfonic acid; In tetrachloromethane; Reflux;
86%
With N-Bromosuccinimide; dibenzoyl peroxide; In chloroform; at 85 ℃; for 24h; Inert atmosphere;
58%
With N-Bromosuccinimide; dibenzoyl peroxide; In chloroform; at 85 ℃; for 24h; Inert atmosphere;
58%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); for 2h; Reflux; Inert atmosphere;
55%
With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 20 ℃; Heating / reflux;
25%
With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 3h; Reflux;
25%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 3h; Heating;
 
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); for 2h; Reflux;
 
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 2h; Heating / reflux;
 
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 2h; Heating / reflux;
 
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 2h; Product distribution / selectivity; Inert atmosphere; Reflux;
 
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 2h; Heating / reflux;
 
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 2h; Heating / reflux;
 
With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 3h; Reflux; Inert atmosphere;
 
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 2h; Inert atmosphere; Reflux;
 
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In acetonitrile; at 70 ℃; for 8h; Large scale;
 
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 2h; Reflux; Inert atmosphere;
 
2-Bromo-5-fluorotoluene
452-63-1

2-Bromo-5-fluorotoluene

2-(bromomethyl)-4-fluorobenzonitrile
421552-12-7

2-(bromomethyl)-4-fluorobenzonitrile

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / Reflux
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 2 h / Reflux; Inert atmosphere
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In N,N-dimethyl-formamide;
 
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 24 h / Reflux
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / Inert atmosphere; Reflux
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; N,N-dimethyl-formamide;
 
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 24 h / Reflux
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / Reflux; Inert atmosphere
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; N,N-dimethyl-formamide;
 

421552-12-7 Upstream products

  • 147754-12-9
    147754-12-9

    4-fluoro-2-methylbenzonitrile

  • 452-63-1
    452-63-1

    2-Bromo-5-fluorotoluene

421552-12-7 Downstream products

  • 865759-24-6
    865759-24-6

    2-[(6-chloro-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]-4-fluorobenzonitrile

  • 1023649-68-4
    1023649-68-4

    2-((dimethylamino)methyl)-4-fluorobenzonitrile

  • 934012-90-5
    934012-90-5

    4-fluoro-2-(methoxymethyl)benzonitrile

  • 1021873-77-7
    1021873-77-7

    5-chloro-1-(2-cyano-5-fluorobenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrochloride

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