CasNo： 1195768-19-4
MF： C14H10F3NO4S
Provided herein are novel C-terminal Srk...
The present invention relates to LIM Kin...
The present disclosure relates to pharma...
The present disclosure pertains to a pha...
3-amino-2-fluorobenzoic acid methyl ester
2,6-difluorobenzene-1-sulfonyl chloride
3-(2,6-difluorobenzenesulfonamido)-2-fluorobenzoic acid methyl ester
| Conditions | Yield |
|---|---|
|
With pyridine; In dichloromethane; at 15 - 25 ℃;
|
91% |
|
With pyridine; In dichloromethane; at 15 - 25 ℃;
|
91% |
|
With pyridine; In dichloromethane; at 15 - 25 ℃;
|
91% |
|
With pyridine; In dichloromethane; at 15 - 25 ℃;
|
91% |
|
With pyridine; In dichloromethane; at 15 - 25 ℃;
|
91% |
|
With pyridine; In dichloromethane; at 15 - 25 ℃;
|
91% |
|
With pyridine; In dichloromethane; at 0 - 20 ℃; for 16h;
|
89% |
|
With pyridine; In dichloromethane; at 20 ℃; Inert atmosphere;
|
87% |
|
With pyridine; In dichloromethane; at 20 ℃;
|
87% |
|
With pyridine; In dichloromethane; at 20 ℃;
|
87% |
|
With pyridine; dmap; In dichloromethane; at 20 ℃; for 12h; Reagent/catalyst; Inert atmosphere;
|
82% |
|
With pyridine; In dichloromethane; at 0 - 20 ℃;
|
62% |
|
With pyridine; In dichloromethane;
|
|
|
With pyridine; at 15 - 20 ℃;
|
6.91 g |
2-fluoro-3-bromobenzoic acid methyl ester
3-(2,6-difluorobenzenesulfonamido)-2-fluorobenzoic acid methyl ester
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 3 steps
1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 90 °C / Sealed tube; Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3: pyridine / dichloromethane / 20 °C
With pyridine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In dichloromethane;
|
|
|
Multi-step reaction with 3 steps
1: caesium carbonate / tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3: pyridine / dichloromethane / 20 °C
With pyridine; caesium carbonate; trifluoroacetic acid; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; toluene;
|
3-amino-2-fluorobenzoic acid methyl ester
2,6-difluorobenzene-1-sulfonyl chloride
3-amino-2-fluoro benzoic acid
methyl 3-((tert-butoxycarbonyl)amino)-2-fluorobenzoate
N-(3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
C31H28F3N7O3S2
N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
dabrafenib
