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  • Product Name3-Amino-2-chloro-4-methylpyridine
  • CasNo. 133627-45-9
  • MFC6H7ClN2
  • MW142.588
  • Purity
  • Appearanceoff white crystals
  • Packing
  • Contact usInquiry

Product Details

CasNo： 133627-45-9

MF： C6H7ClN2

Appearance： off white crystals

Trustworthy Factory Supply Top Purity 133627-45-9 On Stock

  • Molecular Formula:C6H7ClN2
  • Molecular Weight:142.588
  • Appearance/Colour:off white crystals 
  • Vapor Pressure:0.0229mmHg at 25°C 
  • Melting Point:61-64 °C 
  • Refractive Index:1.592 
  • Boiling Point:283.3 °C at 760 mmHg 
  • PKA:3.22±0.10(Predicted) 
  • Flash Point:125.2 °C 
  • PSA：38.91000 
  • Density:1.26 g/cm3 
  • LogP:2.20680 

3-Amino-2-chloro-4-methylpyridine(Cas 133627-45-9) Usage

InChI:InChI=1/C6H7ClN2/c1-4-6(7)5(8)2-3-9-4/h2-3H,1H3,(H2,8,9)

133627-45-9 Relevant articles

A concise synthesis of 2-chloro-3-amino-4-methylpyridine

Ge, Xin,Chen, Han-Geng,Cao, Chang-Hui,Liu, Jin-Qiang,Qian, Chao,Chen, Xin-Zhi

, p. 599 - 604 (2011)

An improved and commercially valuable pr...

Synthesis of 2-cyanoacrylates containing pyridinyl moiety under ultrasound irradiation

Zhang, Huiping,Song, Baoan,Zhong, Huimin,Yang, Song,Jin, Linhong,Hu, Deyu,He, Wei

, p. 1211 - 1214 (2005)

Reaction of ethyl cyanoacetate with carb...

Synthesis, docking study and kinase inhibitory activity of a number of new substituted pyrazolo[3,4-c]pyridines

Sklepari, Meropi,Lougiakis, Nikolaos,Papastathopoulos, Athanasios,Pouli, Nicole,Marakos, Panagiotis,Myrianthopoulos, Vassilios,Robert, Thomas,Bach, Stéphane,Mikros, Emmanuel,Ruchaud, Sandrine

, p. 66 - 81 (2017)

A series of new pyrazolo[3,4-c]pyridines...

Improved synthesis of 2-chloro-3-amino-4-methylpyridine

Zhao, Qian,Chen, Han-Geng,Qian, Chao,Chen, Xin-Zhi

, p. 145 - 148 (2013)

2-Chloro-3-amino-4-methylpyridine (), a ...

DIARYLTHIOHYDANTOIN COMPOUND AS ANDROGEN RECEPTOR ANTAGONIST

-

Paragraph 0205-0207, (2020/07/07)

The present application belongs to the f...

4-methylpiperidine-3-ketone and simple preparation method of 4-methylpiperidine-3-ketone derivative

-

, (2019/11/04)

The invention relates to 4-methylpiperid...

Synthesis and Antiproliferative Activity of New pyrazolo[3,4-c]pyridines

Gavriil, Efthymios-Spyridon,Lougiakis, Nikolaos,Pouli, Nicole,Marakos, Panagiotis,Skaltsounis, Alexios-Leandros,Nam, Sangkil,Jove, Richard,Horne, David,Gioti, Katerina,Pratsinis, Harris,Kletsas, Dimitris,Tenta, Roxane

, p. 365 - 374 (2017/06/21)

Background: Several pyrazolopyridines po...

133627-45-9 Process route

2-chloro-3-nitro-4-methylpyridine
23056-39-5

2-chloro-3-nitro-4-methylpyridine

3-Amino-2-chloro-4-methylpyridine
133627-45-9

3-Amino-2-chloro-4-methylpyridine

Conditions
Conditions Yield
With hydrogenchloride; tin(ll) chloride; In diethyl ether; for 0.333333h; Ambient temperature;
98%
2-chloro-3-nitro-4-methylpyridine; With iron; acetic acid; at 70 - 80 ℃;
With sodium carbonate; In water; pH=8.0 - 8.5; Product distribution / selectivity;
90.79%
2-chloro-3-nitro-4-methylpyridine; With hydrogenchloride; In methanol; water; at 65 ℃;
With iron; In methanol; water; at 65 ℃; Product distribution / selectivity;
90.1%
2-chloro-3-nitro-4-methylpyridine; With phosphoric acid; In water; at 70 - 80 ℃;
With iron; In water; at 70 - 80 ℃; Product distribution / selectivity;
90.7%
With hydrogen; Rh on carbon; In ethanol; for 3h; under 2585.7 Torr;
75%
With sodium dithionite; In methanol; water; at 70 - 80 ℃; Product distribution / selectivity;
72.6%
With hydrogenchloride; tin(ll) chloride; In diethyl ether; at 100 ℃; for 3h;
 
With hydrogenchloride; tin(II) chloride dihdyrate; at 55 ℃;
 
With hydrogenchloride; tin(II) chloride dihdyrate; at 50 ℃; for 1h;
 
With ammonium chloride; zinc; In methanol; dichloromethane; at 15 ℃; for 24h;
 
3-amino-4-methylpyridine
3430-27-1

3-amino-4-methylpyridine

3-Amino-2-chloro-4-methylpyridine
133627-45-9

3-Amino-2-chloro-4-methylpyridine

Conditions
Conditions Yield
With hydrogenchloride; dihydrogen peroxide; at 20 ℃; for 0.5h;
89%
With hydrogenchloride; chlorine; In water; at 20 ℃; for 0.416667h;
84%
3-amino-4-methylpyridine; With hydrogenchloride; In water; at 40 ℃; Cooling with ice;
With dihydrogen peroxide; for 2h;
83.2%
3-amino-4-methylpyridine; With hydrogenchloride; dihydrogen peroxide; In water; at 20 ℃;
With water; sodium carbonate; pH=8;
78%
With hydrogenchloride; sodium hydroxide; chlorine; In water;
 
With hydrogenchloride; sodium hydroxide; chlorine; In water;
23.9 g (84%)
With hydrogenchloride; dihydrogen peroxide; In water; at 0 - 20 ℃; for 1h;
 

133627-45-9 Upstream products

  • 23056-39-5
    23056-39-5

    2-chloro-3-nitro-4-methylpyridine

  • 3430-27-1
    3430-27-1

    3-amino-4-methylpyridine

  • 152362-01-1
    152362-01-1

    2-chloro-4-methyl-3-pyridinecarboxamide

  • 5832-44-0
    5832-44-0

    3-nitro-4-methylpyridine

133627-45-9 Downstream products

  • 133627-46-0
    133627-46-0

    2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide

  • 76006-00-3
    76006-00-3

    3-acetamido-2-chloro-4-methylpyridine

  • 129618-40-2
    129618-40-2

    Nevirapine

  • 133627-47-1
    133627-47-1

    N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide

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