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  • Product Name2-Chloro-3',4'-dihydroxyacetophenone
  • CasNo. 99-40-1
  • MFC8H7ClO3
  • MW186.595
  • Purity
  • Appearance
  • Packing
  • Contact usInquiry

Product Details

CasNo： 99-40-1

MF： C8H7ClO3

Factory Supply Hot Sale 99-40-1 with Lowest Price

  • Molecular Formula:C8H7ClO3
  • Molecular Weight:186.595
  • Melting Point:174-176 °C(lit.) 
  • Boiling Point:418.7 °C at 760 mmHg 
  • PKA:7.59±0.20(Predicted) 
  • Flash Point:207 °C 
  • PSA：57.53000 
  • Density:1.444 g/cm3 
  • LogP:1.51930 

99-40-1 Relevant articles

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Hoberman

, p. 1382 (1935)

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Diazinium salts with dihydroxyacetophenone skeleton: Syntheses and antimicrobial activity

Balan, Ana Maria,Florea, Ondina,Moldoveanu, Costel,Zbancioc, Gheorghita,Iurea, Dorina,Mangalagiu, Ionel I.

, p. 2275 - 2279 (2009)

Herein we report a feasible study concer...

Imidazolylacetophenone oxime-based multifunctional neuroprotective agents: Discovery and structure-activity relationships

Ren, Bo,Guo, Cong,Liu, Run-Ze,Bian, Zhao-Yuan,Liu, Rong-Chun,Huang, Lan-Fang,Tang, Jiang-Jiang

, (2021/12/09)

Alzheimer's disease (AD) possesses a com...

Preparation method of isoproterenol hydrochloride

-

Paragraph 0008; 0029-0032, (2021/05/01)

The invention relates to the technical f...

Acetophenone oxime ester imidazole derivative as well as preparation method and application thereof

-

Paragraph 0032-0037; 0094-0098; 0109-0113, (2021/09/26)

The invention relates to the technical f...

Production process of adrenal glands

-

Paragraph 0028-0030, (2021/11/15)

The invention discloses a production tec...

99-40-1 Process route

benzene-1,2-diol
120-80-9,19481-10-8,37349-32-9

benzene-1,2-diol

chloroacetic acid
79-11-8

chloroacetic acid

2-chloro-3',4'-dihydroxyacetophenone
99-40-1

2-chloro-3',4'-dihydroxyacetophenone

Conditions
Conditions Yield
With thionyl chloride; sodium hydroxide; at 80 ℃; for 5h;
85%
With trichlorophosphate;
 
With boron trifluoride;
 
With trichlorophosphate;
 
benzene-1,2-diol
120-80-9,19481-10-8,37349-32-9

benzene-1,2-diol

chloroacetyl chloride
79-04-9

chloroacetyl chloride

2-chloro-3',4'-dihydroxyacetophenone
99-40-1

2-chloro-3',4'-dihydroxyacetophenone

Conditions
Conditions Yield
With trichlorophosphate; at 105 ℃; for 3h; Microwave irradiation;
93%
With aluminum (III) chloride; In dichloromethane; at 25 ℃; for 5h;
90.3%
benzene-1,2-diol; With aluminum (III) chloride; In 1,2-dichloro-ethane; at 5 ℃; for 0.833333h;
chloroacetyl chloride; In 1,2-dichloro-ethane; at 5 - 20 ℃; for 20h;
85%
benzene-1,2-diol; With aluminum (III) chloride; In 1,2-dichloro-ethane; at 5 - 10 ℃; for 0.5h;
chloroacetyl chloride; In 1,2-dichloro-ethane; at 5 - 20 ℃; for 20h;
74%
benzene-1,2-diol; chloroacetyl chloride; With trichlorophosphate; at 125 ℃; for 4.5h; Neat (no solvent);
With water; at 80 ℃; Neat (no solvent); Heating / reflux;
65%
With aluminum (III) chloride; In dichloromethane; at 0 - 35 ℃;
62%
 
  
With trichlorophosphate; benzene;
 
 
  
With trichlorophosphate; benzene;
 
With aluminium trichloride; In dichloromethane; 1.) reflux, 7 h, 2.) RT, overnight;
 
benzene-1,2-diol; With aluminum (III) chloride; In 1,2-dichloro-ethane; at 10 - 15 ℃; for 0.666667 - 1.16667h;
chloroacetyl chloride; In 1,2-dichloro-ethane; at 10 - 20 ℃; for 16 - 20h;
With hydrogenchloride; water; In 1,2-dichloro-ethane; at 5 - 20 ℃; for 2 - 3h;
 
With aluminum (III) chloride;
 
With aluminum (III) chloride; In carbon disulfide; for 10h; Reflux;
 
 
  
 
  
benzene-1,2-diol; With aluminum (III) chloride; In 1,2-dichloro-ethane; at 5 ℃; for 0.333333h;
chloroacetyl chloride; In 1,2-dichloro-ethane; at 5 - 20 ℃; for 20h; Temperature;
 
With aluminum (III) chloride; In dichloromethane; at 0 - 30 ℃; Large scale;
80 kg

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    benzene-1,2-diol

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    chloroacetic acid

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