CasNo： 55289-05-9
MF： C9H10O3
Proteolysis targeting chimeras (PROTACs)...
The disclosure relates to new compounds,...
The invention discloses a synthesis proc...
The invention discloses a co-production ...
3-hydroxy 2-methylbenzoic acid
methyl 3-hydroxy-2-methylbenzoate
| Conditions | Yield |
|---|---|
|
|
97% |
|
With thionyl chloride; In methanol;
|
|
|
In methanol; thionyl chloride; toluene;
|
|
|
With sulfuric acid; In methanol; Reflux;
|
|
|
With chloro-trimethyl-silane; In methanol; at 20 ℃; for 16h;
|
methanol
3-hydroxy 2-methylbenzoic acid
methyl 3-hydroxy-2-methylbenzoate
| Conditions | Yield |
|---|---|
|
With hydrogenchloride; Heating;
|
100% |
|
With thionyl chloride; In methanol; for 1h; Reflux;
|
100% |
|
With thionyl chloride; at 0 ℃; Reflux;
|
100% |
|
With thionyl chloride; at 50 ℃;
|
98% |
|
With sulfuric acid; at 90 ℃;
|
98% |
|
With sulfuric acid; for 15 - 48h; Product distribution / selectivity; Heating / reflux;
|
97% |
|
With sulfuric acid; for 18h; Reflux;
|
96% |
|
With sulfuric acid; for 6h; Reflux;
|
93% |
|
With thionyl chloride; at 0 - 70 ℃; for 3h; Temperature;
|
93% |
|
With acetyl chloride; at 0 - 20 ℃; for 18h; Product distribution / selectivity;
|
91% |
|
With sulfuric acid; at 65 ℃; for 17h; Inert atmosphere;
|
88.7% |
|
methanol; With acetyl chloride; at 0 - 20 ℃; for 1h;
3-hydroxy 2-methylbenzoic acid; at 20 ℃; for 42h; Product distribution / selectivity;
|
87% |
|
With sulfuric acid; at 62 ℃; for 17h;
|
87% |
|
With sulfuric acid; In methanol; at 62 ℃; for 17h;
|
87% |
|
With sulfuric acid; at 62 ℃; for 17h;
|
87% |
|
With sulfuric acid; at 60 ℃; Inert atmosphere;
|
86% |
|
With thionyl chloride; at 20 - 50 ℃; for 2h;
|
84% |
|
With thionyl chloride; at 0 - 70 ℃; for 2h;
|
84% |
|
With sulfuric acid; at 60 ℃; for 17h;
|
80.4% |
|
methanol; 3-hydroxy 2-methylbenzoic acid; With sulfuric acid; at 60 ℃; for 17h;
With water; at 20 ℃; for 4.5h;
|
80.4% |
|
With sulfuric acid;
|
|
|
With sulfuric acid; at 62 ℃; for 17h;
|
|
|
With sulfuric acid; Inert atmosphere; Reflux;
|
|
|
With thionyl chloride; at 60 ℃;
|
|
|
With sulfuric acid; at 60 ℃; for 17h;
|
|
|
With sulfuric acid; at 60 ℃; for 17h;
|
700 g |
|
With sulfuric acid; at 60 ℃; for 17h;
|
700 g |
|
With sulfuric acid; at 60 ℃; for 17h;
|
700 g |
|
at 85 - 100 ℃;
|
methanol
3-hydroxy 2-methylbenzoic acid
methyl 3-amino-2-methylbenzoate
2-methyl-3-nitro-benzoic acid methyl ester
3-ethoxy-2-methyl-benzoic acid methyl ester
methyl 2-methyl-3-(naphth-2-ylmethoxy)benzoate
methyl 6-bromo-3-hydroxy-2-methylbenzoate
3-methoxy-2-methylbenzoic acid
