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  • Product Name4-(4-methylpiperazin-1-yl)-2-[(tetrahydropyran-4-yl)(2,2,2-trifluoroacetyl)amino]benzoic acid trifluoroacetate
  • CasNo. 1034975-62-6
  • MF
  • MW529.436
  • Purity
  • Appearance
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Product Details

CasNo： 1034975-62-6

Trustworthy Factory Supply Top Purity 99% 1034975-62-6 with Safe Transportation

  • Molecular Formula:C2HF3O2*C19H24F3N3O4
  • Molecular Weight:529.436

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1034975-62-6 Process route

tert-butyl 4-(4-methylpiperazine-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoate
1034975-53-5

tert-butyl 4-(4-methylpiperazine-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoate

trifluoroacetic acid
76-05-1

trifluoroacetic acid

4-(4-methylpiperazine-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt
1034975-62-6

4-(4-methylpiperazine-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt

Conditions
Conditions Yield
In dichloromethane; at 0 - 22 ℃; Inert atmosphere;
99%
In dichloromethane; at 0 - 20 ℃; for 20h;
75%
In dichloromethane; at 20 ℃; for 2h;
 
In dichloromethane; at 20 ℃; for 2h;
 
4-aminotetrahydropyran
38041-19-9

4-aminotetrahydropyran

4-(4-methylpiperazine-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt
1034975-62-6

4-(4-methylpiperazine-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: 1,4-diaza-bicyclo[2.2.2]octane / dimethyl sulfoxide / 16 h / 100 °C / Inert atmosphere
2: triethylamine / dichloromethane / 22 °C
3: nickel(II) bromide dimethoxyethane; 1,4-diaza-bicyclo[2.2.2]octane; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate / dimethyl sulfoxide / 0.5 h / 50 °C / Inert atmosphere; Irradiation; Flow reactor
4: dichloromethane / 0 - 22 °C / Inert atmosphere
With 1,4-diaza-bicyclo[2.2.2]octane; nickel(II) bromide dimethoxyethane; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; triethylamine; In dichloromethane; dimethyl sulfoxide;
 
Multi-step reaction with 4 steps
1: 1,4-diaza-bicyclo[2.2.2]octane / dimethyl sulfoxide / 16 h / 100 °C / Inert atmosphere
2: triethylamine / dichloromethane / 22 °C
3: nickel(II) bromide dimethoxyethane; 1,4-diaza-bicyclo[2.2.2]octane; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate / dimethyl sulfoxide / 1 h / 50 °C / Inert atmosphere; Irradiation; Flow reactor
4: dichloromethane / 0 - 22 °C / Inert atmosphere
With 1,4-diaza-bicyclo[2.2.2]octane; nickel(II) bromide dimethoxyethane; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; triethylamine; In dichloromethane; dimethyl sulfoxide;
 

1034975-62-6 Upstream products

  • 1034975-53-5
    1034975-53-5

    tert-butyl 4-(4-methylpiperazine-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoate

  • 76-05-1
    76-05-1

    trifluoroacetic acid

  • 942271-61-6
    942271-61-6

    tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate

  • 1034975-35-3
    1034975-35-3

    tert‐butyl 2‐amino‐4‐(4‐methylpiperazin‐1‐yl)benzoate

1034975-62-6 Downstream products

  • 1034976-52-7
    1034976-52-7

    4-(4-methylpiperazin-1-yl)-2-[(tetrahydropyran-4-yl)-(2,2,2-trifluoroacetyl)amino]benzoyl chloride

  • 1108745-38-5
    1108745-38-5

    N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzamide

  • 1108743-60-7
    1108743-60-7

    N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide

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